AMINOCYCLOHEXYL ETHER COMPOUND AND USE THEREOF

• Main Authors: PLOUVIER BERTRAND, BARETT ANTHONY G M, CHOU DOUG TA HUNG, ZOLOTOY ALEXANDER, YONG SANDRO L, BEATCH GREGORY N, SHENG TAO, LIU YUZHONG, WALL RICHARD, WALKER MICHAEL J A, CHOI LEWIS SIU LEUNG, ZHU JEFF, JUNG GRACE
• Format: Patent
• Language: English
• Published: 29.03.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To provide an aminocyclohexyl ether compound satisfying the necessity for identifying a new antiarrhythmic treatment in both of atrial arrhythmia and ventricular arrhythmia. SOLUTION: The compound represented by formula (IA) (wherein, R3, R4and R5are each independently selected from hydrogen, hydroxy and 1-6C alkoxy, with the proviso that not all of R3, R4and R5can be hydrogen, but R3, R4and R5can include an isolated enantiomer, a diastereomer, a stereoisomer and a mixture thereof), a solvate thereof, and a pharmacologically acceptable salt, ester, amide, complex, chelate, stereoisomer, stereoisomer mixture, geometric isomer, crystalline form or amorphous form, metabolite, metabolic precursor or prodrug thereof are provided. COPYRIGHT: (C)2007,JPO&INPIT