GLP-1 DERIVATIVE

PROBLEM TO BE SOLVED: To provide a human glucagon-like peptide-1(GLP-1) derivative with a protracted profile of action. SOLUTION: The GLP-1 derivative is such that a lipophilic substituent such as an alkyl or ω-carboxylic acid group is added to the N-terminated or C-terminated amino acid residue. An...

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Bibliographic Details
Main Authors NIELSEN PER FRANKLIN, KNUDSEN LISELOTTE BJERRE, HUUSFELDT PER OLAF
Format Patent
LanguageEnglish
Published 28.12.2006
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a human glucagon-like peptide-1(GLP-1) derivative with a protracted profile of action. SOLUTION: The GLP-1 derivative is such that a lipophilic substituent such as an alkyl or ω-carboxylic acid group is added to the N-terminated or C-terminated amino acid residue. An analogue of this derivative wherein part of the amino acid sequence in this derivative is transformed is also provided. In this derivative, a 2nd lipophilic substituent may be bound to an amino acid residue other than the terminal. The derivative and the analogue each have a more protracted profile of action than the parent GLP-1(7-37). COPYRIGHT: (C)2007,JPO&INPIT
Bibliography:Application Number: JP20060201324