SYSTEM AND METHOD FOR MASS SPECTROMETRY

• Main Authors: YOKOSUKA TOSHIYUKI, OTAKE ATSUSHI, KOBAYASHI KINYA, YOSHINARI KIYOMI
• Format: Patent
• Language: English
• Published: 07.12.2006
• Subjects: BASIC ELECTRIC ELEMENTS; ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS; ELECTRICITY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

PROBLEM TO BE SOLVED: To automatically determine and process peptides derived from a very small amount of proteins as targets of tandem mass spectrometry desired by users without any measurement waste. SOLUTION: In this tandem type analysis system, by ionizing an object to be measured and performing mass spectrometry on generated various ion species, ion species having a specific mass-to-charge ratio are selected from among the generated various ion species and dissociated, and ion mass spectrometry measurement is repeated at n-stages (n=1, 2, etc.). On the basis of ionic strength expressed by a peak to the mass-to-charge ratio of ions in results of MSn, mass spectrometry at the n-th stage, control contents of the next analysis of MSnare determined for every ion to be analyzed. An ionization detector 14 highly precisely collates sample measurement and ionization data and determines the peaks of isotopes. When a count number of MS1of a parent ion peptide measured for some prescribed period is, for example, I, a data processing part 15 makes the number of times of integration of MS2of the peptide or its analysis time proportional to 1/I. COPYRIGHT: (C)2007,JPO&INPIT