RNA APTAMER BINDING TO ABNORMAL TYPE PRION PROTEIN-DERIVED FIBRIL

PROBLEM TO BE SOLVED: To provide a method for detecting a prion disease containing a nucleic acid molecule targeting a PrP (prion protein), especially an RNA molecule targeting an SAF [a scrapie-associated fibril (an abnormal type prion protein-derived fibril)]. SOLUTION: The method is to identify t...

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Bibliographic Details
Main Authors PENMECCHA KUMAR, NODA TAKESHI, NISHIKAWA SATOSHI, YOKOYAMA TAKASHI, SEKIYA SATOSHI
Format Patent
LanguageEnglish
Published 30.11.2006
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide a method for detecting a prion disease containing a nucleic acid molecule targeting a PrP (prion protein), especially an RNA molecule targeting an SAF [a scrapie-associated fibril (an abnormal type prion protein-derived fibril)]. SOLUTION: The method is to identify the nucleic acid molecule binding to the SAF and separate the protein by utilizing the nucleic acid molecule. A nuclease-tolerant RNA aptamer is obtained by the method. A composition for diagnosing the prion disease containing the RNA aptamer and a pharmaceutical composition for prophylaxis or therapy of the prion disease are provided. COPYRIGHT: (C)2007,JPO&INPIT
Bibliography:Application Number: JP20050148411