METHOD FOR EVALUATING BONE OR CARTILAGE DISEASE-TREATING AGENT BY UTILIZING GLUTAMIC ACID TRANSMISSION SYSTEM

• Main Authors: HII EIICHI, TAKARADA TSUYOSHI, YONEDA YUKIO, FUJIMORI SAYUMI
• Format: Patent
• Language: English
• Published: 10.11.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a new means for preventing or treating bone or cartilage diseases by elucidating the mechanism of differentiation and propagation of bone or cartilage cells mediated by a glutamic acid transmission system. SOLUTION: This method for evaluating the effectiveness as the treating agent of the bone or cartilage diseases is comprises using the effects on the glutamic acid transmission system of the bone or cartilage as indices. Concretely, the validity of a material to be tested as the treating agent of the bone or cartilage diseases is evaluated based on the effects on the expressed amount or activity of at least ≥1 glutamic acid transmission signal molecule selected from a glutamic acid transporter, glutamic acid receptor and serine transporter, or serine racemase. COPYRIGHT: (C)2006,JPO&NCIPI