PROLIFERATION CONTROL OF CELL ENCAPSULATED IN ARTIFICIAL ORGAN IN LIVING BODY

• Main Authors: DOHERTY EDWARD J, HOLLAND LAURA M, SCHINSTINE MALCOLM, SHOICHET MOLLY S, GENTILE FRANK T, ALBEE MESSING, HAMMANG JOSEPH P, CAIN BRIAN M, AEBISCHER PATRICK, WINN SHELLEY R
• Format: Patent
• Language: English
• Published: 25.08.2005
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method and a composition for controlling the proliferation of an encapsulated cell which combines various advantages of a proliferating cell and a differentiated nondividing cell. SOLUTION: In the method and composition, the distribution of a cell (namely, the number of cells in a BAO or the present position of cells, or both of them) is controlled, when a cell is encapsulated in BAO. (1) The method and composition modify the cells encapsulated in the BAO and (2) the composition modifies proliferation surface in the BAO. COPYRIGHT: (C)2005,JPO&NCIPI