PROCESS FOR PREPARING 19-NOR-VITAMIN D DERIVATIVE

• Main Authors: OKAMOTO SENTARO, SATOU FUMIE
• Format: Patent
• Language: English
• Published: 21.07.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL METHODS OF ORGANIC CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PROBLEM TO BE SOLVED: To provide a process for preparing a 19-nor-vitamin D derivative. SOLUTION: The process for preparing the 19-nor-vitamin D derivative represented by general formula (3) (wherein, RA denotes a hydrogen atoms, a halogen atom or the like; X1and X2denote each mutually independently a hydrogen atom, a protecting group of a hydroxy group or a solid phase having the protecting group at the end; and Z denotes a 1-26C alkyl group or the like) is carried out as follows. An optically active vinylidene-cyclohexane compound represented by general formula (1) äwherein, RA is the same as described in general formula (3); RB denotes a halogen atom or the like; and X1and X2are each the same as described in general formula (3)} or an enantiomer thereof is reacted with a compound represented by general formula (2) M-Z (2) äwherein, M denotes a hydrogen atom, a BRaRbor the like; and Z is the same as described in general formula (3)}. COPYRIGHT: (C)2005,JPO&NCIPI