METHOD FOR PRODUCING N-METHACRYLOYL-4-CYANO-3-TRIFLUOROMETHYLANILINE AND METHOD FOR STABILIZING THE SAME

PROBLEM TO BE SOLVED: To provide a method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline being an intermediate of bicalutamide useful as a cancerostatic agent stably in high yields and to provide a method for stabilizing N-methacryloyl-4-cyano-3-trifluoromethylaniline. SOLUTION: The m...

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Main Authors ITAYA NOBUSHIGE, KATSURA TADASHI, SHINTAKU TETSUYA, SUGI KIYOSHI
Format Patent
LanguageEnglish
Published 10.03.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Abstract PROBLEM TO BE SOLVED: To provide a method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline being an intermediate of bicalutamide useful as a cancerostatic agent stably in high yields and to provide a method for stabilizing N-methacryloyl-4-cyano-3-trifluoromethylaniline. SOLUTION: The method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor. The method stabilizing N-methacryloyl-4-cyano-3-trifluoromethylaniline comprises allowing a polymerization inhibitor to be present. COPYRIGHT: (C)2005,JPO&NCIPI
AbstractList PROBLEM TO BE SOLVED: To provide a method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline being an intermediate of bicalutamide useful as a cancerostatic agent stably in high yields and to provide a method for stabilizing N-methacryloyl-4-cyano-3-trifluoromethylaniline. SOLUTION: The method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor. The method stabilizing N-methacryloyl-4-cyano-3-trifluoromethylaniline comprises allowing a polymerization inhibitor to be present. COPYRIGHT: (C)2005,JPO&NCIPI
Author ITAYA NOBUSHIGE
SUGI KIYOSHI
SHINTAKU TETSUYA
KATSURA TADASHI
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Snippet PROBLEM TO BE SOLVED: To provide a method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline being an intermediate of bicalutamide useful as a...
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Title METHOD FOR PRODUCING N-METHACRYLOYL-4-CYANO-3-TRIFLUOROMETHYLANILINE AND METHOD FOR STABILIZING THE SAME
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