NEW CERAMIDE DERIVATIVE, AND UTILIZATION THEREOF TO ANTICANCER AGENT OR THE LIKE

• Main Authors: TACHIBANA TARO, TAKAO RYOKO, YOMO KEIJI, OGINO KENJI, AZUMA HIDENORI
• Format: Patent
• Language: English
• Published: 17.02.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

PROBLEM TO BE SOLVED: To provide a new ceramide derivative having improved solubility and membrane-permeability; and to provide a new anticancer agent bringing little side effect by using the ceramide derivative obtained thus. SOLUTION: The new ceramide derivative is represented by formulas (1) to (4). Especially, N-lactylsphingosine of formula (1) or (2) exhibits cell death-inducing activities on a cancer cell, and is useful as the anticancer agent. The possibility that the effective concentration against various kinds of the cancer cells is low and the mechanism of the action is unique is shown. COPYRIGHT: (C)2005,JPO&NCIPI