METHOD FOR SCREENING PHARMACEUTICAL CANDIDATE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for screening pharmaceutical candidate compounds in which development of new pharmaceuticals, particularly exploratory research of new pharmaceuticals is made highly efficiency. SOLUTION: This screening method comprises a testing A, a testing B and/or a test...

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Bibliographic Details
Main Authors ARAKAWA RIKI, KATSUYAMA IWAO, TOKUNAGA MASAO, YAMAMOTO MASA
Format Patent
LanguageEnglish
Published 11.11.2004
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To provide a method for screening pharmaceutical candidate compounds in which development of new pharmaceuticals, particularly exploratory research of new pharmaceuticals is made highly efficiency. SOLUTION: This screening method comprises a testing A, a testing B and/or a testing C. The testing A comprises (1) a step for bringing a heteroprotein into contact with an expressed transformed yeast and a specimen to be examined, (2) a step for culturing the yeast under conditions capable of expressing the protein and (3) a step for measuring growing state of the yeast. The testing B comprises (1) a step for bringing a candidate substance in the specimen to be examined into contact with a heteroprotein and (2) a step for detecting mutual action between the heteroprotein and the candidate. The testing C comprises (1) a step for subjecting the candidate substance in the specimen to be examined to enzymatic reaction by using cytochrome P450 derived from human, (2) a step for analyzing a changing body and/or non-changing body of the candidate substance after enzymatic reaction and (3) a step for referring to the analyzed result, evaluating in vivo kinetics of the candidate substance and selecting a physiologically active substance. COPYRIGHT: (C)2005,JPO&NCIPI
Bibliography:Application Number: JP20030113426