TETRAHYDROBENZINDOLE DERIVATIVE EXHIBITING BINDING ABILITY TO 5-HT7 RECEPTOR AND METABOLICALLY STABLE

PROBLEM TO BE SOLVED: To provide a tetrahydrobenzindole derivative having selective binding ability to a 5-HT7receptor and highly stable against metabolism, and a pharmaceutical composition comprising the compound. SOLUTION: The compound is represented by general formula (I) (wherein R1and R3are eac...

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Bibliographic Details
Main Authors KOYAMA MASAO, KIKUCHI CHIKA, FUJI KAZUYUKI, OKUNO MASAYO, HIRANUMA TOYOICHI
Format Patent
LanguageEnglish
Published 19.08.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a tetrahydrobenzindole derivative having selective binding ability to a 5-HT7receptor and highly stable against metabolism, and a pharmaceutical composition comprising the compound. SOLUTION: The compound is represented by general formula (I) (wherein R1and R3are each a hydrogen atom, a fluorine atom, a chlorine atom or a bromine atom; and R2is a hydroxy group, a fluorine atom, a chlorine atom or a bromine atom, provided that when both R1and R3are a hydrogen atom, R2is a fluorine atom or a chlorine atom). The pharmaceutically acceptable salt thereof is also provided. The pharmaceutical composition comprises the compound. COPYRIGHT: (C)2004,JPO&NCIPI
Bibliography:Application Number: JP20000262597