METHOD FOR INHIBITING REPLICATION OF MAMMAL DNA AND MATERIAL THEREFOR

• Main Authors: TSUTSUMI KENICHI, BABA KENZO, SAITO YASUSHI, KUROIWA YASUYUKI
• Format: Patent
• Language: English
• Published: 03.06.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method for inhibiting replication of a mammal DNA by which the replication of the DNA of a mammal creature is specifically inhibited and antitumor or antiviral effects are taken; and to provide a material usable therefor. SOLUTION: A material inhibiting the replication, such as a protein or peptide of a eukaryote including an amino acid sequence represented by sequence number 2 of the amino acid sequence table as a material for specifically inhibiting the replication of the DNA of the eukaryote is linked to a complex required for originating the DNA replication such as an ORC1 protein. As a result, the replication of the DNA can be stopped by deactivating the original function of the ORG by linking the fragment of an ALF-C protein to an ORC1 protein subunit required for the origination of the DNA replication to shield the protein, and an excellent anticancer or antiviral agent is provided. COPYRIGHT: (C)2004,JPO