PHOSPHORIC ACID OR PHOSPHONIC ACID DERIVATIVE

• Main Authors: NARA FUTOSHI, SHIMOZATO RYUICHI, NISHI TAKEHIDE
• Format: Patent
• Language: English
• Published: 13.05.2004
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PROBLEM TO BE SOLVED: To obtain a phosphoric acid or phosphonic acid derivative, pharmacologically acceptable salts or esters thereof, all having high immunosuppressive activity. SOLUTION: The phosphoric acid or phosphonic acid derivative is represented by formula(I)( wherein, R1and R2are each H, or the like; R3and Ra3are each H or a phosphate group-protecting group; R4is H, a lower alkyl, or the like; (n) is 1-6; X is ethylene group, or the like; Y is a single bond, a 1-10C alkylene group, or the like; Z is O or methylene group; R5is H, a cycloalkyl, an aryl, or the like; R6and R7are each H, a halogen atom, or the like; wherein, when R5is H, Y is a substituted 1-10C alkylene group, or the like ). The pharmacologically acceptable salts or esters of the phosphoric acid or phosphonic acid derivative are also provided, respectively. COPYRIGHT: (C)2004,JPO