CELL CYCLE CONTROL COMPOSITION AND ITS USING METHOD

• Main Authors: GOODRICH DAVID W, WANG NANG-PING, LEE WEN-HWA, LEE EVA Y-H P
• Format: Patent
• Language: English
• Published: 02.10.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a cell cycle control composition for controlling the progress of cell cycle of an organism and its using method; a safe and effective method and composition for reversibly inhibiting the progress of cell cycle of an organism; and a technique which can be used in combination with a curing method inhibiting the oncogenesis of an organism. SOLUTION: A method for controlling the cell cycle progress in a cell which is deficient in functional retinoblastoma tumor suppressor protein is provided. In this method, a biologically active, p110RB carboxy-terminal fragment with 56 kDalton is introduced into a cell to be controlled during the period of cell cycle; and while the viability of the cell is maintained, the cell cycle progress of the cell is changed. COPYRIGHT: (C)2004,JPO