NEW ATPase-LIKE POLYPEPTIDE AND DNA THEREOF

• Main Authors: SHIMAZAKI ATSUYUKI, HASHIMOTO YUTAKA, ODA SATOSHI
• Format: Patent
• Language: English
• Published: 10.06.2003
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a new cancer marker. SOLUTION: This new ATPase-like polypeptide which expresses in a human monocytic cultured cell strain THP-1 and DNA thereof are provided. The polypeptide is a protein having three P type ATPase regions and ten transmembrane regions in the cell membrane and is composed of 1192 amino acid sequences or a splicing variant composed of 1129 amino acid sequences in which 63 amino acids in the cell membrane is deleted. The polypeptide is useful as a new cancer marker, since an expression increase in cancer cells, particularly gastric cancer cells is recognized. COPYRIGHT: (C)2003,JPO