ALVEOLUS SURFACE-ACTIVE PROTEIN

• Main Authors: BENSON BRADLEY J, SCHILLING JR JAMES W, BUCKLEY DOUGLAS I, SCARBOROUGH ROBERT M, WHITE ROBERT T
• Format: Patent
• Language: English
• Published: 22.11.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide proteins having a specific configuration and originated in human SP-18 and SP-5, wherein some of these proteins of analogues having the coded configuration have much decreased cohesive property in comparison with natural proteins, i.e., intramolecular and intermolecular interactions and cohesion mainly owing to a covalent disulfide are decreased and the peptide originated in the SP-5 has not only biological activity but also chemical and physical stabilities. SOLUTION: This protein is a purified polypeptide having ASP activity and the arrangement shown below, or its pharmaceutically permissible salt or amide: X-AA28 -AA29 -AA30 -AA31 -AA32 -AA33 -AA34 -AA35 -Leu-Leu-Ile-Z-Z-Z-Z-Z-Z- Leu-Ile-Z-Z-Z-Ile-Z-Gly-Ala-Leu-Leu-Met-Y.