SULFONAMIDE MATRIX METALLOPROTEINASE INHIBITOR

PROBLEM TO BE SOLVED: To provide a compound which is useful for curing cardiopathy, multiple sclerosis, osteoporosis, etc., as a matrix metalloproteinase inhibitor. SOLUTION: A compound represented by the formula [wherein R and R are each H, an alkyl or a substituted alkyl; R and R are each H, a hal...

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Bibliographic Details
Main Authors PICARD JOSEPH ARMAND, PATT WILLIAM CHESTER, O'BRIEN PATRICK MICHAEL, SHULER KEVON RAY, SLISKOVIC DRAGO ROBERT
Format Patent
LanguageEnglish
Published 23.10.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To provide a compound which is useful for curing cardiopathy, multiple sclerosis, osteoporosis, etc., as a matrix metalloproteinase inhibitor. SOLUTION: A compound represented by the formula [wherein R and R are each H, an alkyl or a substituted alkyl; R and R are each H, a halogen or an alkyl; X is OH or NHOH; and V is O, S, SO2 , NR (wherein R contains H or an alkyl) or CH2 ] or its salt tolerable as a medicine is provided.
Bibliography:Application Number: JP20020035628