METHOD FOR PRODUCING ENAMIDE AND OPTICALLY ACTIVE AMINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide an industrially advantageous method for producing optically active N-protected amine derivatives useful as the intermediates of agricultural chemicals and pharmaceuticals and enamides very useful as the substrates for producing the same by asymmetric reduction. SOLUT...

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Bibliographic Details
Main Authors INOUE KENJI, SUGAWARA MASANOBU, YASUTAKE SEIYA, ILIA DIMITRIEVICH GRIDNEV, AZUMA NATSUKA, IMAMOTO TSUNEO
Format Patent
LanguageEnglish
Published 23.10.2002
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:PROBLEM TO BE SOLVED: To provide an industrially advantageous method for producing optically active N-protected amine derivatives useful as the intermediates of agricultural chemicals and pharmaceuticals and enamides very useful as the substrates for producing the same by asymmetric reduction. SOLUTION: The optically active N-protected amino acid derivatives are produced by condensing ketals which can be prepared from an inexpensive raw material with amides or carbamates in the presence of an acid to form enamides, and asymmetrically reducing the enamides with the use of a hydrogenation catalyst to be prepared from a transition metal complex and an optically active ligand.
Bibliography:Application Number: JP20010106849