BIPHENYL SULFONAMIDES USEFUL AS MATRIX METALLOPROTEINASE INHIBITOR

PROBLEM TO BE SOLVED: To obtain a compound useful as an MMP enzyme inhibitor, used for treating diseases transmitted by a MMP enzyme, including cancer, osteoarthritis, rheumatic joint disease, cardiac failure and inflammation. SOLUTION: This cyclic sulfonamide is represented by formula I (R and R ar...

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Bibliographic Details
Main Authors PATT WILLIAM CHESTER, O'BRIEN PATRICK MICHAEL, BARVIAN NICOLE CHANTEL, SLISKOVIC DRAGO ROBERT
Format Patent
LanguageEnglish
Published 25.09.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain a compound useful as an MMP enzyme inhibitor, used for treating diseases transmitted by a MMP enzyme, including cancer, osteoarthritis, rheumatic joint disease, cardiac failure and inflammation. SOLUTION: This cyclic sulfonamide is represented by formula I (R and R are each hydrogen, an alkyl or a substituted alkyl; R and R are each hydrogen, a halo or an alkyl; X is OH or NHOH) or its pharmaceutically acceptable salt. This cyclic sulfonamide is represented by general formula III or its pharmaceutically acceptable salt.
Bibliography:Application Number: JP20020035616