AQUEOUS SUSPENSION FOR INSTILLATION AND METHOD FOR PRODUCING THE SAME

• Main Authors: TOKUYAMA SATORU, OKAMOTO TOMOYUKI, KISHIMOTO YOKO, KASAMA TOSHIO, OGURO SUSUMU, SAITO KOICHI, HANASOME ISAO
• Format: Patent
• Language: English
• Published: 28.08.2002
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

PROBLEM TO BE SOLVED: To obtain an aqueous suspension for instillation comprising 9-[(2- hydroxyethoxy)methyl]guanine, which contains the therapeutic agent for ocular corneal herpes infectious diseases in a sufficient, and effective amount as an and having excellent stability. SOLUTION: This aqueous suspension for the instillation is characterized in that 0.2-5 wt.% of a fine crystal of the 9-[(2-hydroxyethoxy)methyl]guanine or its pharmaceutically acceptable salt, 0.05-1 wt.% of a partially saponified substance of polyvinyl acetate and 0.01-1 wt.% of a nonionic surfactant are contained and the pH thereof is 6-8. In the aqueous suspension for the instillation, the fine crystal of the 9-[(2-hydroxyethoxy)methyl]guanine or its pharmaceutically acceptable salt which is the active ingredient especially ahs <=50 μ minor axis and <=70 μm major axis in 1:<=10 ratio of the minor axis to the major axis.