METHOD FOR PRODUCING ACETAMINOPHENONE

• Main Authors: FRUCHEY O STANLEY, HILTON CHARLES B, HORLENKO THEODORE, AGUILA DANIEL A, FRITCH JOHN R, SEELIGER WILLIAM J, SNYDER PHILLIP S
• Format: Patent
• Language: English
• Published: 29.01.2002
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

PROBLEM TO BE SOLVED: To produce an N-acetyl-para-aminophenol by bringing 4- hydroxyacetophenone oxime into contact with a Beckmann rearrangement catalyst in an alkali alkanoate reactional solvent. SOLUTION: 4-Hydroxyacetophenone is reacted with a hydroxylamine salt and a base to prepare the 4-hydroxyacetopheonone oxime and the resultant oxime product is then extracted from the resultant reactional mixture with a substantially water-immiscible solvent. The oxime and the substantially water- immiscible solvent are brought into contact with the Beckmann rearrangement catalyst to produce the N-acetyl-para-aminophenol. The formation of a by- product in the ester solvent is limited by using the new Beckmann rearrangement catalyst.