METHOD FOR PRODUCING ACETAMINOPHENONE

PROBLEM TO BE SOLVED: To produce an N-acetyl-para-aminophenol by bringing 4- hydroxyacetophenone oxime into contact with a Beckmann rearrangement catalyst in an alkali alkanoate reactional solvent. SOLUTION: 4-Hydroxyacetophenone is reacted with a hydroxylamine salt and a base to prepare the 4-hydro...

Full description

Saved in:
Bibliographic Details
Main Authors FRUCHEY O STANLEY, HILTON CHARLES B, HORLENKO THEODORE, AGUILA DANIEL A, FRITCH JOHN R, SEELIGER WILLIAM J, SNYDER PHILLIP S
Format Patent
LanguageEnglish
Published 29.01.2002
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
Online AccessGet full text

Cover

More Information
Summary:PROBLEM TO BE SOLVED: To produce an N-acetyl-para-aminophenol by bringing 4- hydroxyacetophenone oxime into contact with a Beckmann rearrangement catalyst in an alkali alkanoate reactional solvent. SOLUTION: 4-Hydroxyacetophenone is reacted with a hydroxylamine salt and a base to prepare the 4-hydroxyacetopheonone oxime and the resultant oxime product is then extracted from the resultant reactional mixture with a substantially water-immiscible solvent. The oxime and the substantially water- immiscible solvent are brought into contact with the Beckmann rearrangement catalyst to produce the N-acetyl-para-aminophenol. The formation of a by- product in the ester solvent is limited by using the new Beckmann rearrangement catalyst.
Bibliography:Application Number: JP20010221199