METHOD FOR MANUFACTURING HYDRAZINE DERIVATIVE
PROBLEM TO BE SOLVED: To provide a method for manufacturing a hydrazine derivative, which is useful as medicines or the like, at a low cost on an industrial scale. SOLUTION: (1) A method for manufacturing a hydrazine derivative by reducing a hydrazone derivative with an amine-borane complex; (2) a m...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
20.11.2001
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | PROBLEM TO BE SOLVED: To provide a method for manufacturing a hydrazine derivative, which is useful as medicines or the like, at a low cost on an industrial scale. SOLUTION: (1) A method for manufacturing a hydrazine derivative by reducing a hydrazone derivative with an amine-borane complex; (2) a method for alkylating a hydrazine derivative with a triacyloxyborohydride complex compound or the like; (3) a method for manufacturing a hydrazine derivative through the reduction and alkylation of a hydrazone derivative with a triacyloxyborohydride complex compound or the like; (4) a method for carrying out reductive alkylation of a hydrazine derivative having a disubstituted reactive nitrogen atom in the presence of an amine-borane complex with a carbonyl compound; (5) a method for manufacturing a trisubstituted hydrazine derivative through the reduction and alkylation of the primary amino group of a hydrazine derivative with a triacyloxyborohydride complex compound and reductive alkylation with a carbonyl compound; and (6) a method for carrying out selective sulfonyl amidation on a secondary amino group of a hydrazine derivative having, on the nitrogen-containing heterocycle, (i) a nitrogen atom having a primary amino group and (ii) a nitrogen atom having the secondary amino group. |
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AbstractList | PROBLEM TO BE SOLVED: To provide a method for manufacturing a hydrazine derivative, which is useful as medicines or the like, at a low cost on an industrial scale. SOLUTION: (1) A method for manufacturing a hydrazine derivative by reducing a hydrazone derivative with an amine-borane complex; (2) a method for alkylating a hydrazine derivative with a triacyloxyborohydride complex compound or the like; (3) a method for manufacturing a hydrazine derivative through the reduction and alkylation of a hydrazone derivative with a triacyloxyborohydride complex compound or the like; (4) a method for carrying out reductive alkylation of a hydrazine derivative having a disubstituted reactive nitrogen atom in the presence of an amine-borane complex with a carbonyl compound; (5) a method for manufacturing a trisubstituted hydrazine derivative through the reduction and alkylation of the primary amino group of a hydrazine derivative with a triacyloxyborohydride complex compound and reductive alkylation with a carbonyl compound; and (6) a method for carrying out selective sulfonyl amidation on a secondary amino group of a hydrazine derivative having, on the nitrogen-containing heterocycle, (i) a nitrogen atom having a primary amino group and (ii) a nitrogen atom having the secondary amino group. |
Author | NAKAMURA MINORU MIZUFUNE HIDEYA MIKI MASATAKA YAMAMOTO HIROAKI |
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Snippet | PROBLEM TO BE SOLVED: To provide a method for manufacturing a hydrazine derivative, which is useful as medicines or the like, at a low cost on an industrial... |
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Title | METHOD FOR MANUFACTURING HYDRAZINE DERIVATIVE |
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