METHOD FOR MANUFACTURING HYDRAZINE DERIVATIVE

• Main Authors: MIKI MASATAKA, NAKAMURA MINORU, MIZUFUNE HIDEYA, YAMAMOTO HIROAKI
• Format: Patent
• Language: English
• Published: 20.11.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

PROBLEM TO BE SOLVED: To provide a method for manufacturing a hydrazine derivative, which is useful as medicines or the like, at a low cost on an industrial scale. SOLUTION: (1) A method for manufacturing a hydrazine derivative by reducing a hydrazone derivative with an amine-borane complex; (2) a method for alkylating a hydrazine derivative with a triacyloxyborohydride complex compound or the like; (3) a method for manufacturing a hydrazine derivative through the reduction and alkylation of a hydrazone derivative with a triacyloxyborohydride complex compound or the like; (4) a method for carrying out reductive alkylation of a hydrazine derivative having a disubstituted reactive nitrogen atom in the presence of an amine-borane complex with a carbonyl compound; (5) a method for manufacturing a trisubstituted hydrazine derivative through the reduction and alkylation of the primary amino group of a hydrazine derivative with a triacyloxyborohydride complex compound and reductive alkylation with a carbonyl compound; and (6) a method for carrying out selective sulfonyl amidation on a secondary amino group of a hydrazine derivative having, on the nitrogen-containing heterocycle, (i) a nitrogen atom having a primary amino group and (ii) a nitrogen atom having the secondary amino group.