NITROGEN-CONTAINING CYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To obtain a new compound having excellent calcium antagonism, in particular neuroselective calcium antagonism. SOLUTION: This new compound is represented by the formula [Ar is a (substituted) 5- to 14-membered aromatic cyclic group, or the like; ring A is either one ring select...

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Main Authors KIMURA MANAMI, SHINMYO DAISUKE, KANEDA YOSHIHISA, KANEKO TOSHIHIKO, KURUSU NOBUYUKI, YOSHIKAWA YUKIE, TERAMOTO TETSUYUKI, YAMAMOTO NOBORU, NIITOME TETSUHIRO, SUZUKI YUICHI, HATAKEYAMA SHINJI, IIMURA YOICHI
Format Patent
LanguageEnglish
Published 02.10.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain a new compound having excellent calcium antagonism, in particular neuroselective calcium antagonism. SOLUTION: This new compound is represented by the formula [Ar is a (substituted) 5- to 14-membered aromatic cyclic group, or the like; ring A is either one ring selected from piperazine, homopiperazine and piperidine rings, and the like; ring B is a (substituted) 3-14C hydrocarbon ring, or the like; E is a single bond, a group of the formula CO, or the like; X is a single bond, oxygen atom, or the like; R1 is H, a halogen atom, OH, or the like; and D1, D2, W1 and W2 are each a single bond or a (substituted) 1-6C alkylene chain]. This new compound may assume a salt or hydrate form.
Bibliography:Application Number: JP20010009591