NEW INHIBITOR FOR PRENYL PYROPHOSPHATE-CONSUMING ENZYME

• Main Authors: VAN BOOM JACOBUS HUBERTUS, BURM BRIGITTE ELISA ANNA, VAN DEN ELST HANS, PIETERMAN ELSBET JANTINE, VAN DER MAREL GIJSBERT ARIE, COHEN LOUIS HARTOG, VOSKUYL NICOLETTE, OVERHAND MARK
• Format: Patent
• Language: English
• Published: 12.06.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

PROBLEM TO BE SOLVED: To display that a food is polluted. SOLUTION: This inhibitor for prenyl pyrophosphate-consuming enzyme which is a peptide analogue is a compound represented by the following formula (1) or (2): (1) A-B-D: or (2) A-B-B'-D [wherein, A is Ap-(CH2)0-3- Z1-(CH2)0-3-(CHR1)0-1-Y-; B and B' are each -NR2-(CH2)0-3-Z2-(CH2)0-3-CHR3-Y- or formula (3) independently and at least either of B and B' contain at least four chains of an atom, i.e., B and/or B' contain at least one CH2 when the Z2 is direct bond; and D is -NH-CH(COX)-R4] or a salt or a ester thereof.