OLIGONUCLEOTIDE OF HIGH CHIRAL PURITY BEARING PHOSPHOROTHIOATE LINKAGE

PROBLEM TO BE SOLVED: To obtain an oligonucleotide of high chiral purity bearing a phosphorothioate linkage. SOLUTION: This oligonucleotide is obtained by chemical and enzymatical methods for synthesizing a phosphorothioate oligonucleotide in which all the nucleotide units are substantially connecte...

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Bibliographic Details
Main Authors HOKE GLENN, COOK PHILIP DAN
Format Patent
LanguageEnglish
Published 17.04.2001
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:PROBLEM TO BE SOLVED: To obtain an oligonucleotide of high chiral purity bearing a phosphorothioate linkage. SOLUTION: This oligonucleotide is obtained by chemical and enzymatical methods for synthesizing a phosphorothioate oligonucleotide in which all the nucleotide units are substantially connected together by either all the Sp phosphorothioate saccharide linkages or all the Rp phosphorothioate saccharide linkages, preferably a phosphorothioate oligonucleotide complementary to at least a part of target RNA or DNA sequence and a sequence peculiar phosphorothioate oligonucleotide bearing a substantially chirally pure saccharide linkage.
Bibliography:Application Number: JP20000262871