MEDICINAL COMPOSITION CONTAINING ANTI-Fas ANTIBODY

PROBLEM TO BE SOLVED: To obtain a medicinal composition capable of reducing the tolerance in the patient's body against the anti-Fas antibody and administering for a long period by including a specific anti-Fas antibody and a such specific compound as to enhance effect of the anti-Fas antibody....

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Bibliographic Details
Main Authors ICHIKAWA KIMIHISA, SERIZAWA NOBUKI, KODA HIROKO
Format Patent
LanguageEnglish
Published 13.02.2001
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain a medicinal composition capable of reducing the tolerance in the patient's body against the anti-Fas antibody and administering for a long period by including a specific anti-Fas antibody and a such specific compound as to enhance effect of the anti-Fas antibody. SOLUTION: This medicinal composition comprises, as active ingredients, (A) antihuman Fas antibody having an activity of inducing apoptosis and (B) a compound having an antagonism to folic acid or an effect of inhibiting dihydrofolate reductase. The component A is preferably monoclonal antibody CH11 or its humanized antibody, etc., especially preferably antihuman Fas antibody HFA7A which mouse-mouse hybridoma HFE7A (FERM BP-5828) produces or its humanized antibody. The component B is preferably one or two or more compounds selected from methotrexate, edatrexate, epiroprim, etc. Further, the composition is useful as preventives or remedies for autoimmune diseases or rheumatoid arthritis.
Bibliography:Application Number: JP20000152283