DIAGNOSIS OF PANCREATIC CANCER BY DETECTING ABNORMALITY IN CHROMOSOME

• Main Authors: KISHIMOTO TOSHIHIKO, NIWA SHINICHIRO, JITSUKAWA TOMOFUMI, SASAKI ISANORI
• Format: Patent
• Language: English
• Published: 23.01.2001
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

PROBLEM TO BE SOLVED: To provide a method capable of adequately diagnosing pancreatic cancer, objectively suspecting the progress of pancreatic cancer, and selecting the best treatment for each patient, by detecting deletion in human chromosome-1 long arm-23 to 25 and the like. SOLUTION: This method comprises diagnosing pancreatic cancer by detecting deletion in human chromosome-1 long arm-23 to 25, human chromosome-5 short arm-14 to short arm-ter, human chromosome-5 long arm-14 to 23, human chromosome-1 long arm, human chromosome-13 long arm and the like in chromosomes of a cancer cell derived from a patient. It is preferable to detect deletion or the like by identifying a label at each site so as to be able to observe a chromosome site to which DNA of a cancer cell hybridized with the first label, a chromosome site to which DNA of a normal cell hybridized with the second label, and a chromosomal site to which both DNA hybridized with a mixture of the first and second labels by competitively hybridizing a chromosome of a normal cell with DNA labelled with the first label of a cancer cell derived from a patient and DNA labelled with the second label of a normal cell.