OXATOMIDE PHARMACEUTICAL PREPARATION

• Main Authors: MINEMURA TAKESHI, TAKAGI SHIGEO
• Format: Patent
• Language: English
• Published: 26.12.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PROBLEM TO BE SOLVED: To obtain an oxatomide pharmaceutical preparation having a slight fluctuation in absorption coefficient and high absorbability and capable of stably developing effects of oxatomide by formulating the oxatomide with specific vitamins. SOLUTION: This pharmaceutical preparation is obtained by formulating (A) oxatomide with (B) a tocopherol. The ingredient B in an amount of 1-20 times expressed in terms of weight ratio and based on the ingredient A is formulated in the above pharmaceutical preparation. All the homologs of the tocopherol are included in the ingredient B and may be derived from a natural product or a substance prepared by chemical synthesis may be used. When pharmacodynamic effects of the ingredient B itself are expected in the pharmaceutical preparation, α-tocopherol or a tocopherol mixture consisting essentially of the α-tocopherol is advantageously used. In the above pharmaceutical preparation, δ-tocopherol is preferred in order to dissolve the ingredient A, reduce the fluctuation in the expected absorption coefficient of the ingredient A and raise the absorbability. The dosage form of the pharmaceutical preparation is preferably a capsule.