MEDICINAL COMPOSITION

• Main Authors: ONIKI TAKAYUKI, ISHIGURO KEIJI
• Format: Patent
• Language: English
• Published: 17.10.2000
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

PROBLEM TO BE SOLVED: To obtain an aqueous medicinal composition which possesses a specific range of gel transition temperature T, shows a liquid state at a temperature lower than T and a gel state at a temperature of T or above and exerts improved medicine retentivity in the diseased part by including a gel formable substance. SOLUTION: By including a gel formable substance (e.g. a polyvinylacetal diethylaminoacetate or the like), the aqueous medicinal composition which possesses gel transition temperature T (G) in a range of 5-40 deg.C and shows a liquid state at a temperature lower than the above T (G) and a gel state at a temperature of T (G) or above is obtained. The above gel formable substance is included in an amount capable of controlling the temperature T (G) in the above temperature range, preferably at 10-37 deg.C. For example, in the case of a polyvinyl acetal diethylamino-acetate, it is included in a proportion of 0.1-15 wt.%, preferably 0.1-15 wt.%, based on the composition. As the medicinal composition, the composition for oral cavity (particularly a peridontal disease therapeutic agent, a hyperesthesia therapeutic agent or a dental calculus suppressive agent) is preferably illustrated.