PRESERVING CONTAINER FOR WEAKLY ACIDIC SOLUTION PREPARATION CONTAINING HUMAN GROWTH HORMONE AND CARTRIDGE FOR INJECTION OF THE SAME AS WELL AS METHOD FOR PRESERVATION OF THE SAME

• Main Authors: MORITA SHIGETOSHI, TANAKA KATSUMI, YOSHIMOTO ATSUSHI
• Format: Patent
• Language: English
• Published: 17.10.2000
• Edition: 7
• Subjects: ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; BABY COMFORTERS; CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS,e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES,DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; CONVEYING; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR RECEIVING SPITTLE; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PACKAGES; PACKAGING ELEMENTS; PACKING; PERFORMING OPERATIONS; STORING; TRANSPORTING

PROBLEM TO BE SOLVED: To make it possible to supply a phsycochemically stable human growth hormone(HGH) solution pharmaceutical preparation by forming a second closing member of rubber which contains surfactant and has the prescribed value or below of the elution rate of polyvalent metal ions measured by an atomic absorption method after one piece is immersed into a buffer solution of a prescribed pH and is shaken and preserved at prescribed temperature. SOLUTION: A container body 12 of an approximately cylindrical shape possessed by the preserving container 10 for the HGH-containing weakly acidic solution pharmaceutical preparation forms a lumen 14 and is opened by apertures 16 and 8 at the ends. A diametrally reduced mouth part 20 at one end is mounted with a cap 22 made of the thin rubber and a metallic cap 24. A rubber plug 28 is inserted from another aperture 18 to form a hermetically closed room 32 where the aqueous HGH solution 34 is housed. The rubber plug 28 is formed of the rubber which contains the surfactant and is of about <=50 ppm in the elution rate of the polyvalent metal ions when the elution rate of the polyvalent metal ions in the buffer solution is measured by the atomic absorption method after one piece the rubber plug 28 is immersed into 1 ml buffer solution of the pH about 5.5 to 6.5 and is shaken for one week at 25 deg.C.