PRODUCTION OF MALONATE

PROBLEM TO BE SOLVED: To obtain the subject compound by a method other than traditional one by reacting an alkaline metal salt of malonic acid with a halide in the presence of water and a phase transfer catalyst. SOLUTION: This compound is obtained by reacting an alkaline metal salt of malonic acid...

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Bibliographic Details
Main Authors HANSELMANN PAUL DR, HILDBRAND STEFAN
Format Patent
LanguageEnglish
Published 25.07.2000
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PROBLEM TO BE SOLVED: To obtain the subject compound by a method other than traditional one by reacting an alkaline metal salt of malonic acid with a halide in the presence of water and a phase transfer catalyst. SOLUTION: This compound is obtained by reacting an alkaline metal salt of malonic acid (preferably disodium malonate) with a halide shown by the formula R-X (R is a 1-10C alkyl or the like; and X is chlorine, bromine or the like) in the presence of water and a phase transfer catalyst. The alkaline metal salt is used in the form of aqueous solution, which is preferably obtained by catalytically oxidizing 1,3-propanediol in the presence of an aqueous hydroxide of alkaline metal. The phase transfer catalyst is preferably of a quaternary ammonium salt (more preferably chloride or bromide). It is preferable to use the halide at 80 to 150 deg.C and above atmospheric pressure, when it is a low- boiling compound. It is also preferable to use an inert solvent immiscible with water (e.g. chlorobenzene).
Bibliography:Application Number: JP20000001898