6,7-ASYMMETRIC DISUBSTITUTED QUINOXALINE-CARBOXYLIC ACID, ITS ADDITION SALT AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain the subject new compound which is an antagonistic drug for excitable amino acid receptor antagonist drugs, especially selective antagonistic drugs against non-NDM receptors and useful for curing cerebral nerve cell lesion. SOLUTION: This invention relates to a 6,7-asy...

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Main Authors ASANO JUN, UCHIKI HIDEJI, FUKUCHI KAZUNORI, AMADA JUNICHIRO, ANDOU NAOKI, TAKANO YASUO, ANRAKU TAKESHI, SHIGA FUTOSHI, TAKADOI MASANORI
Format Patent
LanguageEnglish
Published 21.03.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To obtain the subject new compound which is an antagonistic drug for excitable amino acid receptor antagonist drugs, especially selective antagonistic drugs against non-NDM receptors and useful for curing cerebral nerve cell lesion. SOLUTION: This invention relates to a 6,7-asymmetric disubstituted quinoxalinecarboxylic acid derivative expressed by formula I (Q is a halogen, a lower alkyl or the like; R1 is an aralkyl, phenyl, naphthyl, a 5- or 6-membered heterocycle or the like; R2 is hydroxy, a lower alkoxy or the like; R is nitro, trifluoromethyl, amono or the like) and its addition salt, e.g. 7-(3- [(4- carboxyphenyl)aminocarbonylamino]methyl}pyrrol-1-yl)-3,4-dihydro-3-oxo-6- trifluoromethylquinoxaline-2-carboxylic acid. The compound of formula I in which R1 is H is obtained by reacting a compound of formula II (R12 is a lower alkyl or the like) at 20-120 deg.C for 0.5-72 hours using a suitable acid.
Bibliography:Application Number: JP19980291295