5,5-DIALKOXY-2-OXAZOLIDINONE COMPOUNDS AND THEIR PRODUCTION

• Main Authors: YAMAMOTO YASUHITO, ATAKA KIKUO, MIYATA HIROYUKI, HONMA TAKASHI, SATAKE NOBUYA
• Format: Patent
• Language: English
• Published: 11.01.2000
• Edition: 7
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PROBLEM TO BE SOLVED: To obtain a new 5,5-dialkoxy-2-oxazolidinone compound useful as an intermediate for producing α-amino acid esters which are the technical products or intermediates of medicines.agrochemicals and easily giving the α-amino acid esters in high yields. SOLUTION: A compound of formula I [R1 is H, a 1-10C alkyl or the like; R2 is H, phenyl or the like; R3 is a 1-10C alkyl, a 3-10C cycloalkyl or the like; R4 is H or a group of formula II (R6 is H, a 2-10C alkenyl or the like; R7 is a 1-10C alkyl, phenyl or the like); R5 is phenyl, a 2-10C alkenyl or the like], for example, 3-diphenylmethyl-4-(1-methoxy-1-phenylmethyl)-5,5-dimethoxy-2- oxazolidinone. The compound of formula I is obtained by reacting a 5-alkoxy-2(3 H)-oxazolone compound of formula III with an oxygen-containing organic compound of the formula: R4-OR5 (preferably benzaldehyde dimethylacetal, etc.), in the presence of a catalyst (preferably trifluoromethane sulfonic acid, etc.).