URICOSURIC AGENT

PROBLEM TO BE SOLVED: To produce a uricosuric agent useful for the treatment of gout and other hyperuricacidemia by including a specific compound having uricosuric action as an active component. SOLUTION: The objective agent contains a compound having uricosuric action and expressed by formula I (A...

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Bibliographic Details
Main Authors TOMIYAMA ITARU, TOMIYAMA TAKESHI, FUTAMURA MASAYUKI, YOKOTA MASAYUKI, KAMIYAMA NAOTO
Format Patent
LanguageEnglish
Published 07.01.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PROBLEM TO BE SOLVED: To produce a uricosuric agent useful for the treatment of gout and other hyperuricacidemia by including a specific compound having uricosuric action as an active component. SOLUTION: The objective agent contains a compound having uricosuric action and expressed by formula I (A is O or the like; B is O or the like; R1 is H or the like; R2 is a lower alkyl or the like; R3 is H or the like; R4 is nitro or the like) or its pharmacologically permissible salt (e.g. 4'-methyl-1,1'- biphenyl-2-carbonitrile) as an active component. The compound of formula I can be produced e.g. by reacting a compound of formula II (e.g. 2- bromobenzonitrile) with a compound of formula III (B is baron) (e.g. 4- methylbenzeneboronic acid) in the presence of a catalyst such as tetrakistriphenylphosphinepalladium chloride and a base such as potassium carbonate in a solvent such as toluene at room temperature or under heating. The daily administration rate of the compound of formula I for adult is preferably 5-200 mg.
Bibliography:Application Number: JP19980166905