Process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate and its purification for use as pharmaceutically active compound

• Main Authors: Dr. Konrad SIEGEL, Dr. Joachim REHSE, Dr. Winfried JOENTGEN, Dr. Franz-Josef MAIS
• Format: Patent
• Language: Arabic; English
• Published: 27.08.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

يتعلق الاختراع الحالي بعملية (process) لتحضير methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate من الصيغة (I) : (I), وبعملية لتنقية المنتج الخام من المركب من الصيغة (I) للاستخدام كمركب نشط دوائيا ( pharmaceutically active compound ) ، حيث، للتنقية، يعزل methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1)، يعني مركب من الصيغة (II) ، كمركب وسطي أو ينتج كمركب وسطي في عملية التنقية هذه، من المناسب وجوده في خليط. The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) (I), and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.