PROCESSO DI PREPARAZIONE DI MODAFINIL FORMA POLIMORFA(I)

A process is described for preparing polymorphic form (I) of modafinil with high yields and with low impurity content. The process comprises the steps of (a) reacting (diphenylmethyl)thioacetic acid with a C1-C5 alcohol,(b) oxidation of the resulting ester with hydreogen peroxide to give an ester of...

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Bibliographic Details
Main Authors VALENTINCIC MAURIZIO, CONSOLANDI EMANUELA, FERRARI MASSIMO, GHEZZI EMANUELE
Format Patent
LanguageItalian
Published 27.12.2004
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process is described for preparing polymorphic form (I) of modafinil with high yields and with low impurity content. The process comprises the steps of (a) reacting (diphenylmethyl)thioacetic acid with a C1-C5 alcohol,(b) oxidation of the resulting ester with hydreogen peroxide to give an ester of (diphenylmethyl)sulphinylacetic acid, (c) reaction with ammonia to form modafinil and (d) treatement with water and ethyl acetate. This process may comprise a further crystallisation in the presence of a mixture of DMF and acetone to further lower the impurities, and finally a possible crystallisation from DMF and water to increase its particle size.
Bibliography:Application Number: IT2003MI01298