IMPIEGO DI DERIVATI DELLA GONADOLIBERINA PER PREPARARE COMPOSIZIONI FARMACEUTICHE INIBENTI TUMORI

• Main Authors: TAMAS GULYAS, ISTVAN TEPLAN, BALAZS SZOKE, ANIKO HORVATH, GYORGYI BOKONYI, ORSOLYA CSUKA, AGNES BALOGH, ROBERT I. NICHOLSON, GYORGYI KERI
• Format: Patent
• Language: Italian
• Published: 11.05.1989
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pharmaceutical compositions for treating hormone-dependent tumours without inducing hormonal castration contain a gonadoliberin derivative of general formula (I), Gip-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 (I) wherein X1 stands for a glycyl group or a D-isomer of any native or synthetic aromatic D-amino acid group; X2 stands for an L-amino acid group bearing a C1-4alkyl or L-phenylalanyl or L-tryptophyl group; X3 stands for an L-amino-acid residue bearing a C1-4alkyl or C2-4alkanoyl amide side chain; and X4 means a glycyl amide or C1-4alkyl amide group, with the proviso that X3 means a group different from leucyl when X2 stands for a tryptophyl group and X1 is other than glycyl group, its addition salts formed with pharmaceutically acceptable acids or metal complexes.