DERIVATI ACETILENICI CLORURATI DI ANDROST-4-ENE DOTATI DI ATTIVITA'FARMACOLOGICA E PROCEDIMENTO PER LA LORO PREPARAZIONE

Novel 21-chloro-20-acetylenic steroids of the formula I wherein R1 is alkyl of 1 to 3 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine,...

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Bibliographic Details
Main Authors DERAEDT ROGER, TEUTSCH JEAN G, COSTEROUSSE GERMAIN
Format Patent
LanguageItalian
Published 24.10.1980
Edition3
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Novel 21-chloro-20-acetylenic steroids of the formula I wherein R1 is alkyl of 1 to 3 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine, Y is selected from the group consisting of hydrogen, fluorine and methyl and the dotted lines in the A and B rings are one or two optional double bonds in the 1(2) and 6(7) positions with the proviso that Y is not hydrogen when R1 is methyl, X is hydrogen, the A ring is saturated in the 1(2) position and the B ring is saturated having a remarkable anti-inflammatory activity and their preparation.
Bibliography:Application Number: IT19800049999