DERIVATI DEL DIBENZO [A,D] CICLOEPTENE E PROCEDIMENTO PER LA LORO PRODUZIONE

Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula (I) wherein R1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R2 and R3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula These novel compounds are useful as...

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Bibliographic Details
Main Authors SHIN-ICHI YAMADA, KAZUYOSHI OKUTANI, TETSUTARO HAYASAKA, KUNIRO SAITO, TERUO SAITO, TAKAO GOTO, SEN-ICHI NARITA
Format Patent
LanguageItalian
Published 29.09.1980
Edition3
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula (I) wherein R1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R2 and R3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula (I) can be prepared, for example, by cyclizing a compound of the general formula (II) wherein R1 and R2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula -CH2COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group.
Bibliography:Application Number: IT19800025000