COMPOSIZIONI FARMACEUTICHE A RILASCIO CONTROLLATO OSMOTICO E PER DIFFUSIONE DEL FARMACO E PROCEDIMENTO PER LA LORO PREPARAZIONE

• Main Authors: KIRALY NATA IGNACZ MARIA, GORA NATA HERNYES MAGDOLNA, KISS NATA SZABO GIZELLA, JAMBOR NATA HOFFMANN ZSUZSANNA, KLEBOVICH IMRE, FEKETE PAL, SIPOS GABOR, UJFALUSSY GYORGY, KRISZTIAN MARIA, DRABANT IMRE, MANDI ATTILA, BARCZAY ERZSEBET
• Format: Patent
• Language: Italian
• Published: 26.05.1997
• Edition: 6
• Subjects: BABY COMFORTERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A subject-matter of the invention is a diffusion-osmotic controlled drug-release one-layer or two-layer pharmaceutical tablet core (10) containing one or more therapeutically active principle(s) and a hydrophilic polymer and being coated with a polymeric film-coat (11), in case of a two-layer tablet core containing the active principle(s) and hydrophilic polymer in the first layer (14) thereof and hydrophilic polymer in the second layer (15) thereof, and the tablet core (10) further having at least one bore (13; 16) on the film-coat (11) in contact with the tablet core (10) [in case of one-layer tablet core] or on the part of the film-coat (11) in contact with the first tablet core layer (14) containing the active principle(s) [in case of two-layer tablet core], characterized in that the hydrophilic polymer is hydroxypropyl-methylcellulose and the coating material of the film-coat (11) contains an ammonium methacrylate copolymer or a mixture of such. Furthermore according to the invention there is provided for a process for preparing these tablet cores.