Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid

The solubility and stability of basic pharmaceuticals (I) in mixts. of mono- an di-glycerides of 6-12C fatty acids are improved by adding to (I) free 6-18C (6-10C) fatty acids. The resulting salts are then dissolved in the glyceride mixt. Better resorption of (I) from the gastro-intestinal tract. Th...

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Bibliographic Details
Main Authors HEMPEL REINHARD, WISCHNIEWSKI MARTIN, ECKERT THEODOR, KEMPER FRITZ H
Format Patent
LanguageEnglish
Italian
Published 26.08.1985
Edition4
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The solubility and stability of basic pharmaceuticals (I) in mixts. of mono- an di-glycerides of 6-12C fatty acids are improved by adding to (I) free 6-18C (6-10C) fatty acids. The resulting salts are then dissolved in the glyceride mixt. Better resorption of (I) from the gastro-intestinal tract. The fatty acid salts of (I) are more soluble in the glyceride mixt. than free bases or hydrochlorides.
Bibliography:Application Number: IT19780024036