INHIBITORS OF BETA SECRETASE

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the ß secretase enzyme (BACEl) activity pharmaceutical compositions containing the same and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders disorders characteriz...

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Main Authors RAST GEORG, LALA DEEPAK S, MORALES RAMOS ANGEL, DORNER CIOSSEK CORNELIA, ZHENG YAJUN, JIA LANQI, YUAN JING, CACATIAN SALVACION, XU ZHENRONG, SINGH SURESH B, ZHAO YI, DILLARD LAWRENCE WAYNE, BUKHTIYAROV YURI, VENKATRAMAN SHANKAR, FUCHS KLAUS, REEVES JONATHAN
Format Patent
LanguageEnglish
Published 22.05.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the ß secretase enzyme (BACEl) activity pharmaceutical compositions containing the same and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders disorders characterized by cognitive decline cognitive impairment dementia and diseases characterized by production of ß amyloid aggregates.
Bibliography:Application Number: IN2014DELNP6710