"STRAIN INDEPENDENT ANTI-INFLUENZA PEPTIDES FOR TARGETING A NOVEL DRUG SITE IN HEMAGGLUTININ TRIMER"

The invention relates to the generation of solution structural model of influenza hemagglutinin trimer having full glycosylation to identify a novel druggable site and design peptides reactive to this drug site and experimentally evaluate ability of the peptides to block pH-induced shape change/aggr...

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Bibliographic Details
Main Authors RATHORE, YOGENDRA SINGH, PANDEY, KALPANA, ASHISH
Format Patent
LanguageEnglish
Published 05.06.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to the generation of solution structural model of influenza hemagglutinin trimer having full glycosylation to identify a novel druggable site and design peptides reactive to this drug site and experimentally evaluate ability of the peptides to block pH-induced shape change/aggregation of the hemagglutinin (HA) protein. These peptides and their analogs block the fusion of the HA protein with its receptors in the endosome of host cells in a strain independent manner.
Bibliography:Application Number: IN2012DEL411