PROCESS FOR THE PREPARATION OF THIAZOLIDINECARBOXYLIC ACID DERIVATIVES

• Main Authors: JAKAB ATTILA, NEE BORBELY ILDIKO MIHOK DR, BOGNAR REZSO DR, PUSZTAI FERENC DR, HORVATH GEZA DR, KOVACS ISTVAN DR, MILE TEREZIA DR, JENEI ANDRAS DR, GYORGYDEAK ZOLTAN DR, NEE HAM JUDIT KRUSPER, BALINT JANCS DR, LAPIS KAROLY DR, NEE HUSZKA MARIANN FEKETE, SZENDE BELA DR, JANCSO SANDOR DR
• Format: Patent
• Language: English
• Published: 02.12.1989
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel thiazolidine-4(S)-carboxylic acid derivatives of the general formula (I) (I) wherein R1 stands for an optionally substituted furyl, pyrrolyl, thienyl, benzofuryl, benzopyrrolyl, benzothienyl, phenyl, pyridyl, quinolinyl, isoquinolinyl or indanyl group or a C1-4 alkyl or C2-4 alkenyl group optionally substituted by a hydroxyl, carboxyl or halogen fenoxy group, stands for hydrogen, an alkaline metal or an alkaline earth metal atom or an optionally substituted C1-4 alkyl group or aryl group; R3 represents hydrogen or an optionally substituted C1-4 alkyl or acyl group or aryl group as well as their salts. Further on, the invention relates to pharmaceutical preparations containing these compounds and to a process for preparing these compounds and preparations. The compounds of the invention are useful for treating or preventing liver damages of either natural or experimental origin.