A PROCESS FOR PREPARING NEW AMINOACRIDINE L-AND/OR B-(D)-N-GLYCOSIDE AND/OR AMINOACRIDINE-L-AND/OR B-(L)-N-GLYCOSIDE AND/OR O-ACETYL DERIVATIVES AND THEIR SALTS

• Main Authors: JANOSSY LORANT, NANASI PAL, POLYA KALMAN, CSERNUS ISTVAN, LIPTAK ANDRAS, ERDEI JANOS, NESZMELYI ANDRAS, KOVACS ANTAL, KASZAB ISTVAN
• Format: Patent
• Language: English
• Published: 18.05.1985
• Edition: 4
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention relates to novel aminoacridine- alpha , beta -(D)- and -(L)-N-glycoside derivatives, the salts thereof and to a novel process for the preparation of such compounds and salts. The novel compounds have the formula I I wherein R is hydrogen or a group of the formula II II wherein n=0 or 1, p=1 or 2, A-p is an anion, preferably halogenide, R1 is hydrogen or a methyl group and R2 is hydrogen or a sugar residue, or R is dimethylamine, and the two substituents X and X1 are identical or different and stand for hydrogen, a group of the formula II, dimethylamine, halogen, a C1-4 alkyl group, a C1-4 alkoxy group, for a nitro-, cyano-, carbomethoxy-, carbamoyl-, phenyl- or a C1-4 alkylphenyl group, with the restriction that at least one of the substituents R, X and X1 represents a group of formula II with R2=sugar residue, and R3 is hydrogen or a C1-5 alkyl group.