ZOLE DERIVATES PROCESS FOR THE PREPARATION OF SULFUR CONTAINING BENZIMIDA

A process for the preparation of anthelmintic compounds of the formula: wherein R1 is hydrogen or -COOR; R5 is C1 to C4 alkyl; R2 is halogen, alkyl, trifluoromethyl, alkoxy, aryloxy, or aralkoxy; and R4 is hydrogen, alkyl, cycloalkyl; alkenyl, alkynyl or aralkyl; or pharmaceutically acceptable salts...

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Bibliographic Details
Main Authors CSER GABORNE, HEJA GERGELY, PALOSI BNDRE, KORBONITS DEZSO, SZVOBODA GYORGYNE, KISS PAL, KELENEN ANDRAS, CONCAI CSABA, KORNOCAI GYORGY, SZOMOR TIBORNE
Format Patent
LanguageEnglish
Published 24.04.1982
Edition3
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRAPPING
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Summary:A process for the preparation of anthelmintic compounds of the formula: wherein R1 is hydrogen or -COOR; R5 is C1 to C4 alkyl; R2 is halogen, alkyl, trifluoromethyl, alkoxy, aryloxy, or aralkoxy; and R4 is hydrogen, alkyl, cycloalkyl; alkenyl, alkynyl or aralkyl; or pharmaceutically acceptable salts thereof comprises subjecting a bis compound of the formula: to reduction to cleave the disulfide linkage and where R4 is other then hydrogen, subsequent reaction of the mercapto group. Intermediate compounds and a process for preparing same are also disclosed.
Bibliography:Application Number: IN505CA1978