Antibodies and antigen binding peptides for factor xia inhibitors and uses thereof

The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect o...

Full description

Saved in:
Bibliographic Details
Main Authors LUETTGEN Joseph M, AN Yongmi, SCHNEEWEIS Lumelle, PINCKNEY Jason Robert, YAMNIUK Aaron Paul, RAKESTRAW Ginger Chao, SHERIFF Steven, KRYSTEK JR. Stanley Richard, KISH Kevin, EWING William R, DILGER Andrew Karl, TERRAGNI Christina
Format Patent
LanguageEnglish
Hebrew
Published 01.09.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
Online AccessGet full text

Cover

More Information
Summary:The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect of FXIa inhibitors by administering to a subject a pharmaceutically effective dose of the antigen binding peptides provided herein. In addition, the present invention provides detection reagents and methods for detecting the level of the inhibitors of FXIa in a biological sample.
Bibliography:Application Number: IL20230304210