Macrocycles with hetrocyclic p2' groups as factor xia inhibitors

The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention als...

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Main Authors YANG Wu, DILGER Andrew K, CORTE James R, FANG Tianan, WEXLER Ruth R, SMITH Leon M. II, WANG Yufeng, ORWAT Michael J, DE LUCCA Indawati, PINTO Donald J. P, PABBISETTY Kumar Balashanmuga, EWING William R, ZHU Yeheng
Format Patent
LanguageEnglish
Hebrew
Published 01.03.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and these compounds for use in therapy.
AbstractList The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and these compounds for use in therapy.
Author ZHU Yeheng
WANG Yufeng
PABBISETTY Kumar Balashanmuga
PINTO Donald J. P
SMITH Leon M. II
ORWAT Michael J
DE LUCCA Indawati
FANG Tianan
DILGER Andrew K
WEXLER Ruth R
CORTE James R
YANG Wu
EWING William R
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– fullname: WANG Yufeng
– fullname: ORWAT Michael J
– fullname: DE LUCCA Indawati
– fullname: PINTO Donald J. P
– fullname: PABBISETTY Kumar Balashanmuga
– fullname: EWING William R
– fullname: ZHU Yeheng
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DocumentTitleAlternate מקרוציקלינים עם קבוצות הטרוציקליות p2' כמעכבי פקטור xia
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PABBISETTY Kumar Balashanmuga
PINTO Donald J. P
SMITH Leon M. II
ORWAT Michael J
DE LUCCA Indawati
FANG Tianan
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BRISTOL-MYERS SQUIBB COMPANY
WEXLER Ruth R
CORTE James R
YANG Wu
EWING William R
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Snippet The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
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